Guarding genome integrity in stem cells

Genome integrity, stem cells and hyaluronan

Faithful preservation of genome integrity is the critical mission of stem cells as well as of germ cells. Reviewed are the following mechanisms involved in protecting DNA in these cells: (a) The efflux machinery that can pump out variety of genotoxins in ATP-dependent manner; (b) the mechanisms maintaining minimal metabolic activity which reduces generation of reactive oxidants, by-products of ...

Integrity-Aware Bandwidth Guarding Approach in P2P Networks

Most Internet-based collaborative computing systems face the major problem: freeriding. The abundance of freeriders, and load imbalance it creates, punishes those peers who do actively contribute to the network by forcing them to overuse their resources. Hence, the overall system performance becomes to degrade quickly. The goal of this paper is aimed to provide an efficient approach to distingu...

Genomic Integrity of Mouse Embryonic Stem Cells

Analyzing the genomic integrity of stem cells

Prolonged culture of pluripotent and multipotent stem cells exposes the cells to strong selection pressures, often resulting in genomic alterations. Any genetic manipulation of the cells may further jeopardize their genomic stability. Genomic aberrations affect the differentiation capacity of stem cells, their stem cell identity and their tumorigenicity, and should thus be routinely evaluated f...

Stem ‍Cells in Glaucoma Management

Glaucoma is the leading cause of preventable blindness worldwide. Despite tremendous advances in medical and surgical management of glaucoma in the recent years, the prevalence of glaucoma related blindness is anticipated to increase in the future decades because of the aging population. Stem cells have the potential to change the glaucoma management in several ways. There are several areas of ...